Cosmic Breath Journeys - Intimate Group Experience

$0.00

THE COSMIC BREATH

SUNDAY JAN 18, 2025 | 6-10pm

Begin the New Year with a Sacred MeO-5-DMT Journey, held intimately with loving presence, facilitated by Kat & Phoenix.

You’re invited to gather with us for a ceremonial crossing between what has been and what is waiting to emerge.

This journey is designed as an energetic cleansing and profound attunement to the frequency of your 2026 destiny.

Join us for a special night of purification, remembrance, and rebirth.

Our next group ceremony will be held Sunday, January 18th, 2026 in Kerrisdale Vancouver, co-facilitated with Phoenix Amara ~ a deeply held evening of healing, connection, and inner awakening.

This evening will start with an intention circle, breathwork, and facilitated MeO-5-DMT / The God Molecule session in an intimate setting at the Chalice in Kerrisdale, Vancouver B.C. To consider joining this group, please book a consult call or join our private signal group.

This evening holds a maximum number to ensure spaciousness and presence is held for each individual.

WHAT’S INCLUDED:

30-45 min Consult - Intake & Preparation Call with either Kathy Gibson or Phoenix Amara

• 4-hour session with Breathwork, Energetic Support & The 5-Medicine

• Group Integration Call (Scheduled a week after the journey)

Exchange: Dana Exchange (Please Read Below). Deposit is required before ceremony to hold your space in the container.

Experience 

the God Molecule

DMT Integration & Consciousness Coaching 

Prepare. Surrender. Integrate.

SACRED EXCHANGE

WHAT’S INCLUDED

  • 30-45 Min | Intake & Preparation Call

  • In-person Ceremony (4 hours) plus Medicine

  • 90-Min Group Integration Call

  • Tea & community nourishing snack upon completion

DANA MODEL OF EXCHANGE:

This ceremony is offered in the spirit of Dana—an ancient model of sacred reciprocity and generosity. Rather than a fixed fee, you are invited to contribute what feels aligned, respectful, and abundant based on what you receive and what you are able to give. If you're unsure how to determine an amount, consider how much you earn per hour, and how many hours of support, preparation, ceremony, and integration we offer (typically 3–6 hours total). This is a powerful medicine, and your contribution helps sustain this work with care, integrity, and accessibility for others.

Some people have offered upwards of $1k-2k for their ceremony and have abundance to contribute towards their experience, others have contributed between $100-$500 for their ceremonies. Give from a place that feels honouring of both your journey and mine. Exchange for each person sitting is part of the divine reciprocity…but you will not be turned away for lack of funds either.

Start by first booking your initial consult call below. From there, if it feels aligned, you can reserve your spot in the ceremony with deposit.

Book your Free Consult Calll Here

There are moments in life that dissolve everything we thought we knew. Moments when the veils lift and we glimpse the infinite.

Whether you’ve already journeyed with DMT or are feeling called toward that threshold, having a guide who understands the sacred, psychological, and somatic dimensions of this experience can make all the difference.

EXPAND YOURSELF

SIT WITH THE INFINITE &

This psychedelic session is designed to support you before and after your experience, so you can ground its insights into your daily life.

Each session is tailored to your unique path and includes:

  • Preparation: Setting clear intentions, understanding the psychic terrain, and learning grounding techniques.

  • Integration: Making sense of mystical visions, emotions, and revelations through dialogue, embodiment, and creative process.

  • Somatic Grounding: Techniques to anchor back into the body and nervous system after expanded states.

  • Mythic Mapping: Exploring what your journey reveals about your personal story of transformation.

Clear out the old energies and prepare your vessel for the visions, prayers and dreams ready to greet you.

Frequently Asked Questions

  • What is DMT?

    MeO-5-DMT is a naturally occurring psychoactive compound known for inducing profound states of ego dissolution, divine union, and non-dual awareness. Often referred to as "The God Molecule," this sacred medicine has been used in shamanic and spiritual practices to support deep spiritual awakening and inner transformation.

    What is MeO-5-DMT?
    Derived from the secretions of the Sonoran Desert toad (Bufo alvarius) or synthesized in a lab (which is what I use - often termed ‘vegan DMT’,) MeO-5-DMT is one of the most potent entheogens known. Unlike other psychedelics, it often leads to a rapid and total dissolving of identity into the experience of pure unity, love, and source consciousness.

    How Can It Help? This medicine may support:

    • Dissolution of long-held trauma and limiting patterns

    • A profound remembrance of one’s true nature

    • Emotional release, clarity, and nervous system reset

    • Reconnection with purpose, divinity, and love

Who is this for?

  • Those who are ready to experience the power of DMT or have previously sat with the God Molecule.

  • Those ready to feel, embody and experience their Godself, communicate with their higher self, and experience the beauty of this powerful medicine.

  • People with depression, anxiety, or PTSD. Early research and surveys of users suggest that a single MeO-5-DMT session can lead to rapid and sustained improvements in symptoms of depression, anxiety, and post-traumatic stress disorder.

  • Those seeking spiritual or mystical experiences. Many users are drawn to MeO-5-DMT for spiritual exploration. Studies indicate that the intensity of a profound mystical experience is often linked to greater reported improvements in mental well-being and life satisfaction.

  • Those interested in ego dissolution. MeO-5-DMT is known for its ability to induce a powerful sense of ego dissolution, or a feeling of oneness with the universe. This experience can be profoundly transformative for some individuals, leading to a shift in perspective on their place in the world.

  • Those in good physical and mental health. Certain medications can create complications with 5MEO, which is why we book an initial consult to determine if this experience is for you.

What can I expect?

Each ceremony is held with utmost care, safety, and reverence. We first meet virtually or on a call for 30-45 minutes to discuss your intentions, questions, and any concerns. You’ll be guided through reflection, embodiment, and grounding practices designed to help you integrate your insights and restore inner balance.

Then in-person sessions are typically 1:1 (or can be small groups of people) and include:

  • Preparation and intention setting

  • Somatic grounding and breathwork

  • A guided ceremonial experience with MeO-5-DMT

  • Post-journey integration, emotional support & reflection call (usually booked within 3-7 days of an experience).

The journey itself is short—usually 10–30 minutes—but the effects can ripple for months, sometimes years. Participants may experience sensations of timelessness, ego death, radiant bliss, or deep catharsis. Integration is key.

Note: This work is not recreational and is not for everyone. You will be guided with compassion, trauma-informed care, and full consent every step of the way. We determine in the intake call if this experience is for you & if there are any medical issues that would complicate an experience.

Where is this held?

This ceremony will be held in the The Chalice Mansion venue in Kerrisdale, Vancouver.

Meet Your Guides

Kat Gibson is a trained Psychedelic Guide & Integration Facilitator with direct experiential understanding with various medicines. She is deeply committed to co-creating experiences for the highest of all her participants. She supports clearings, healing, alignment, and heightened human consciousness by pairing transformational medicine ceremony with her enormous repertoire of energetic work. 

She invites and inspires others in their soul’s evolution, utilizing her own  soul remembrance and a lifetime of spiritual insights through multiple esoteric modalities. She is fulfilling her dharma, in soul-aligned flow, when being in service to the collective and invites you to sit with her and feel held in love from every step of the experience for lasting transformation and personal evolution. 

Kat blends eight years of study of ancient ceremonial shamanic practices with various modalities, some of which include:

  • Psychedelic Facilitation—Shamanic lineage & including Toad School DMT Facilitator Training with Dr. Trina Nguyen

  • Reiki Master, originally attuned by her Father in Usui/Holy Fire III Reiki lineage

  • Certified Spinal Energetics Practitioner, trained by Dr. Sarah Jane – a blend of 12 modalities

  • NeuroChange Solutions Trainer with Dr. Joe Dispenza

  • Certified Somagetic Practitioner trained with Nathan Marcuzzi including: Somatic Embodiment, DeArmouring, Ecstatic Experiences, Somatic Releases

  • Breathwork Facilitator – various trainings, modalities and methods

  • Cold & Heat Exposure Facilitator

Trainings in Tantra, meditation, quantum healing, energy & abundance activations, manifestation, guided visualization, hypnosis, nervous system regulation, chakra balancing, tuning forks, sound healing, light language, Body Talk, women’s embodiment and womb work, men’s work (e.g.Sacred Sons retreat facilitation), Akashic records, coaching, channelling, and other deep ancient healing techniques. 

Kat does 1:1 soul mentorship, is a published best selling author, international facilitator & teaches her signature program CAP: Cosmic Abundance Program Jan 7-& co-developed several programs including: 

Join us and receive deep spiritual connection, emotional release, energetic realignment, and transmutation of trauma & deeply felt experiences. Kat’s unique energetic support enhances the transformative potential from this experience. Connect with her on IG.

Meet Your Guides

Phoenix Amara is an internationally recognized ceremonialist, writer, and sacred sexuality guide devoted to bridging the worlds of mysticism, art, and consciousness. Over the past decade, she has sat in dozens of Ayahuasca ceremonies and has direct experiential understanding with DMT, 5-MeO-Bufo, Psilocybin, LSD, and MDMA as tools for healing and awakening.

Having facilitated hundreds of ceremonies and transformational journeys for clients around the world, Phoenix also supports individuals in preparing for, sitting with and integrating psychedelic experiences with a grounded, somatic, and heart-centered approach. Her work weaves together sacred ritual, nervous system regulation, archetypal psychology, and embodiment practices to help people translate expanded states into lasting transformation.

Before dedicating her life to this path, Phoenix earned degrees in Visual Arts and Environmental Design, and spent years exploring esoteric studies, metaphysics, and the erotic arts. She’s the founder of Temple Arts Alchemy, a body of work exploring the intersection of soul, sex, and art, and host of the HOLY EROS Podcast, where she interviews visionaries and experts on consciousness, intimacy, and spiritual awakening.

Phoenix is also the author of the forthcoming memoir, Ascension of Gaia: The Resurrection of the Sacred Sexual Feminine, which chronicles her own initiatory healing through plant medicine and embodiment.

Her background includes training in somatic therapy, neo-tantra, authentic relating, non-violent communication, energy work, and psychedelic facilitation——including Toad School DMT Facilitator Training with Dr. Trina Nguyen, Somatic Embodiment Training, and DeArmouring with Nathan Marcuzzi. She is currently completing the Clinical Somatic Sexology Certification through the Somatica Institute.

Additional trainings include Breathwork training with Somatic Embodiment Training Level 1, Authentic Relating Level 1 (Communication/Relating), Non-Violent Communication Training (Conflict/Repair), Personal Power Level 1 with Lori-Ann Demers (Empowerment), Red Lotus Tantra Certification with Olivia Jade, Usui Reiki Levels 1, 2 & 3, Diploma of Visual Arts, Bachelors of Environmental Design, and feminine leaderships trainings with Nisha Moodley, Emily Utter, Year Long Love Leadership Mentorship with Kamala Devi, Coaching with Margie Pargie and others. Connect with her on IG.

FOR YOUR CEREMONY

HOW TO PREPARE

Your journey begins long before you sit with the 5. We invite you to approach this experience with reverence and intention. Here are some tips which is recommended, in order to properly prepare for your experience.

DAY OF: Take time to rest, clear your schedule, and create a calm, nourishing space for yourself. Write out your intentions in your journal. Create a nourishing day of peace for yourself. Sit quietly with your intentions & ask your heart what you are ready to release, receive, or remember. Allow the day itself to be spacious and gentle, free from unnecessary distractions, so you may enter the ceremony open, centered, and attuned to the wisdom awaiting you.

Fast for 2–3 hours beforehand to support clarity of body and mind, avoiding heavy foods or stimulants. try to avoid caffeine, alcohol, marijuana or any other substances, so you can be clear about your journey.

HOW TO BOOK

Please start by filling out a brief application & booking a free 30-min consult form. This will give us a chance to connect, discuss your needs and desires, select a date and also answer any questions about sessions. (And don’t worry, all info submitted in your application for the consult is kept 100% confidential).

BOOK FREE CONSULT HERE

Once we have a connection call & determine that this experience is for you, we’ll schedule in your session and you can send in a Deposit to hold session date.

Deposits: Can be done via e-transfer & Remainder of your Dana Exchange for In-person Session can be made via cash gift in person or e-transfer after session.

Availability: Our availability does tend to book quickly due to demand, so please anticipate that session bookings will happen within 2-3 weeks after our initial consult. Cancellations? Life happens. As long as you can give me 48 hours notice before cancelling a session, I’m happy to rebook once for a later date. Sessions cancelled within 24 hours will not be refunded nor moved unless certain situations require it (medical emergencies etc).

Additional Resources 

https://www.nature.com/articles/d41591-025-00062-4

THE COSMIC BREATH

SUNDAY JAN 18, 2025 | 6-10pm

Begin the New Year with a Sacred MeO-5-DMT Journey, held intimately with loving presence, facilitated by Kat & Phoenix.

You’re invited to gather with us for a ceremonial crossing between what has been and what is waiting to emerge.

This journey is designed as an energetic cleansing and profound attunement to the frequency of your 2026 destiny.

Join us for a special night of purification, remembrance, and rebirth.

Our next group ceremony will be held Sunday, January 18th, 2026 in Kerrisdale Vancouver, co-facilitated with Phoenix Amara ~ a deeply held evening of healing, connection, and inner awakening.

This evening will start with an intention circle, breathwork, and facilitated MeO-5-DMT / The God Molecule session in an intimate setting at the Chalice in Kerrisdale, Vancouver B.C. To consider joining this group, please book a consult call or join our private signal group.

This evening holds a maximum number to ensure spaciousness and presence is held for each individual.

WHAT’S INCLUDED:

30-45 min Consult - Intake & Preparation Call with either Kathy Gibson or Phoenix Amara

• 4-hour session with Breathwork, Energetic Support & The 5-Medicine

• Group Integration Call (Scheduled a week after the journey)

Exchange: Dana Exchange (Please Read Below). Deposit is required before ceremony to hold your space in the container.

Experience 

the God Molecule

DMT Integration & Consciousness Coaching 

Prepare. Surrender. Integrate.

SACRED EXCHANGE

WHAT’S INCLUDED

  • 30-45 Min | Intake & Preparation Call

  • In-person Ceremony (4 hours) plus Medicine

  • 90-Min Group Integration Call

  • Tea & community nourishing snack upon completion

DANA MODEL OF EXCHANGE:

This ceremony is offered in the spirit of Dana—an ancient model of sacred reciprocity and generosity. Rather than a fixed fee, you are invited to contribute what feels aligned, respectful, and abundant based on what you receive and what you are able to give. If you're unsure how to determine an amount, consider how much you earn per hour, and how many hours of support, preparation, ceremony, and integration we offer (typically 3–6 hours total). This is a powerful medicine, and your contribution helps sustain this work with care, integrity, and accessibility for others.

Some people have offered upwards of $1k-2k for their ceremony and have abundance to contribute towards their experience, others have contributed between $100-$500 for their ceremonies. Give from a place that feels honouring of both your journey and mine. Exchange for each person sitting is part of the divine reciprocity…but you will not be turned away for lack of funds either.

Start by first booking your initial consult call below. From there, if it feels aligned, you can reserve your spot in the ceremony with deposit.

Book your Free Consult Calll Here

There are moments in life that dissolve everything we thought we knew. Moments when the veils lift and we glimpse the infinite.

Whether you’ve already journeyed with DMT or are feeling called toward that threshold, having a guide who understands the sacred, psychological, and somatic dimensions of this experience can make all the difference.

EXPAND YOURSELF

SIT WITH THE INFINITE &

This psychedelic session is designed to support you before and after your experience, so you can ground its insights into your daily life.

Each session is tailored to your unique path and includes:

  • Preparation: Setting clear intentions, understanding the psychic terrain, and learning grounding techniques.

  • Integration: Making sense of mystical visions, emotions, and revelations through dialogue, embodiment, and creative process.

  • Somatic Grounding: Techniques to anchor back into the body and nervous system after expanded states.

  • Mythic Mapping: Exploring what your journey reveals about your personal story of transformation.

Clear out the old energies and prepare your vessel for the visions, prayers and dreams ready to greet you.

Frequently Asked Questions

  • What is DMT?

    MeO-5-DMT is a naturally occurring psychoactive compound known for inducing profound states of ego dissolution, divine union, and non-dual awareness. Often referred to as "The God Molecule," this sacred medicine has been used in shamanic and spiritual practices to support deep spiritual awakening and inner transformation.

    What is MeO-5-DMT?
    Derived from the secretions of the Sonoran Desert toad (Bufo alvarius) or synthesized in a lab (which is what I use - often termed ‘vegan DMT’,) MeO-5-DMT is one of the most potent entheogens known. Unlike other psychedelics, it often leads to a rapid and total dissolving of identity into the experience of pure unity, love, and source consciousness.

    How Can It Help? This medicine may support:

    • Dissolution of long-held trauma and limiting patterns

    • A profound remembrance of one’s true nature

    • Emotional release, clarity, and nervous system reset

    • Reconnection with purpose, divinity, and love

Who is this for?

  • Those who are ready to experience the power of DMT or have previously sat with the God Molecule.

  • Those ready to feel, embody and experience their Godself, communicate with their higher self, and experience the beauty of this powerful medicine.

  • People with depression, anxiety, or PTSD. Early research and surveys of users suggest that a single MeO-5-DMT session can lead to rapid and sustained improvements in symptoms of depression, anxiety, and post-traumatic stress disorder.

  • Those seeking spiritual or mystical experiences. Many users are drawn to MeO-5-DMT for spiritual exploration. Studies indicate that the intensity of a profound mystical experience is often linked to greater reported improvements in mental well-being and life satisfaction.

  • Those interested in ego dissolution. MeO-5-DMT is known for its ability to induce a powerful sense of ego dissolution, or a feeling of oneness with the universe. This experience can be profoundly transformative for some individuals, leading to a shift in perspective on their place in the world.

  • Those in good physical and mental health. Certain medications can create complications with 5MEO, which is why we book an initial consult to determine if this experience is for you.

What can I expect?

Each ceremony is held with utmost care, safety, and reverence. We first meet virtually or on a call for 30-45 minutes to discuss your intentions, questions, and any concerns. You’ll be guided through reflection, embodiment, and grounding practices designed to help you integrate your insights and restore inner balance.

Then in-person sessions are typically 1:1 (or can be small groups of people) and include:

  • Preparation and intention setting

  • Somatic grounding and breathwork

  • A guided ceremonial experience with MeO-5-DMT

  • Post-journey integration, emotional support & reflection call (usually booked within 3-7 days of an experience).

The journey itself is short—usually 10–30 minutes—but the effects can ripple for months, sometimes years. Participants may experience sensations of timelessness, ego death, radiant bliss, or deep catharsis. Integration is key.

Note: This work is not recreational and is not for everyone. You will be guided with compassion, trauma-informed care, and full consent every step of the way. We determine in the intake call if this experience is for you & if there are any medical issues that would complicate an experience.

Where is this held?

This ceremony will be held in the The Chalice Mansion venue in Kerrisdale, Vancouver.

Meet Your Guides

Kat Gibson is a trained Psychedelic Guide & Integration Facilitator with direct experiential understanding with various medicines. She is deeply committed to co-creating experiences for the highest of all her participants. She supports clearings, healing, alignment, and heightened human consciousness by pairing transformational medicine ceremony with her enormous repertoire of energetic work. 

She invites and inspires others in their soul’s evolution, utilizing her own  soul remembrance and a lifetime of spiritual insights through multiple esoteric modalities. She is fulfilling her dharma, in soul-aligned flow, when being in service to the collective and invites you to sit with her and feel held in love from every step of the experience for lasting transformation and personal evolution. 

Kat blends eight years of study of ancient ceremonial shamanic practices with various modalities, some of which include:

  • Psychedelic Facilitation—Shamanic lineage & including Toad School DMT Facilitator Training with Dr. Trina Nguyen

  • Reiki Master, originally attuned by her Father in Usui/Holy Fire III Reiki lineage

  • Certified Spinal Energetics Practitioner, trained by Dr. Sarah Jane – a blend of 12 modalities

  • NeuroChange Solutions Trainer with Dr. Joe Dispenza

  • Certified Somagetic Practitioner trained with Nathan Marcuzzi including: Somatic Embodiment, DeArmouring, Ecstatic Experiences, Somatic Releases

  • Breathwork Facilitator – various trainings, modalities and methods

  • Cold & Heat Exposure Facilitator

Trainings in Tantra, meditation, quantum healing, energy & abundance activations, manifestation, guided visualization, hypnosis, nervous system regulation, chakra balancing, tuning forks, sound healing, light language, Body Talk, women’s embodiment and womb work, men’s work (e.g.Sacred Sons retreat facilitation), Akashic records, coaching, channelling, and other deep ancient healing techniques. 

Kat does 1:1 soul mentorship, is a published best selling author, international facilitator & teaches her signature program CAP: Cosmic Abundance Program Jan 7-& co-developed several programs including: 

Join us and receive deep spiritual connection, emotional release, energetic realignment, and transmutation of trauma & deeply felt experiences. Kat’s unique energetic support enhances the transformative potential from this experience. Connect with her on IG.

Meet Your Guides

Phoenix Amara is an internationally recognized ceremonialist, writer, and sacred sexuality guide devoted to bridging the worlds of mysticism, art, and consciousness. Over the past decade, she has sat in dozens of Ayahuasca ceremonies and has direct experiential understanding with DMT, 5-MeO-Bufo, Psilocybin, LSD, and MDMA as tools for healing and awakening.

Having facilitated hundreds of ceremonies and transformational journeys for clients around the world, Phoenix also supports individuals in preparing for, sitting with and integrating psychedelic experiences with a grounded, somatic, and heart-centered approach. Her work weaves together sacred ritual, nervous system regulation, archetypal psychology, and embodiment practices to help people translate expanded states into lasting transformation.

Before dedicating her life to this path, Phoenix earned degrees in Visual Arts and Environmental Design, and spent years exploring esoteric studies, metaphysics, and the erotic arts. She’s the founder of Temple Arts Alchemy, a body of work exploring the intersection of soul, sex, and art, and host of the HOLY EROS Podcast, where she interviews visionaries and experts on consciousness, intimacy, and spiritual awakening.

Phoenix is also the author of the forthcoming memoir, Ascension of Gaia: The Resurrection of the Sacred Sexual Feminine, which chronicles her own initiatory healing through plant medicine and embodiment.

Her background includes training in somatic therapy, neo-tantra, authentic relating, non-violent communication, energy work, and psychedelic facilitation——including Toad School DMT Facilitator Training with Dr. Trina Nguyen, Somatic Embodiment Training, and DeArmouring with Nathan Marcuzzi. She is currently completing the Clinical Somatic Sexology Certification through the Somatica Institute.

Additional trainings include Breathwork training with Somatic Embodiment Training Level 1, Authentic Relating Level 1 (Communication/Relating), Non-Violent Communication Training (Conflict/Repair), Personal Power Level 1 with Lori-Ann Demers (Empowerment), Red Lotus Tantra Certification with Olivia Jade, Usui Reiki Levels 1, 2 & 3, Diploma of Visual Arts, Bachelors of Environmental Design, and feminine leaderships trainings with Nisha Moodley, Emily Utter, Year Long Love Leadership Mentorship with Kamala Devi, Coaching with Margie Pargie and others. Connect with her on IG.

FOR YOUR CEREMONY

HOW TO PREPARE

Your journey begins long before you sit with the 5. We invite you to approach this experience with reverence and intention. Here are some tips which is recommended, in order to properly prepare for your experience.

DAY OF: Take time to rest, clear your schedule, and create a calm, nourishing space for yourself. Write out your intentions in your journal. Create a nourishing day of peace for yourself. Sit quietly with your intentions & ask your heart what you are ready to release, receive, or remember. Allow the day itself to be spacious and gentle, free from unnecessary distractions, so you may enter the ceremony open, centered, and attuned to the wisdom awaiting you.

Fast for 2–3 hours beforehand to support clarity of body and mind, avoiding heavy foods or stimulants. try to avoid caffeine, alcohol, marijuana or any other substances, so you can be clear about your journey.

HOW TO BOOK

Please start by filling out a brief application & booking a free 30-min consult form. This will give us a chance to connect, discuss your needs and desires, select a date and also answer any questions about sessions. (And don’t worry, all info submitted in your application for the consult is kept 100% confidential).

BOOK FREE CONSULT HERE

Once we have a connection call & determine that this experience is for you, we’ll schedule in your session and you can send in a Deposit to hold session date.

Deposits: Can be done via e-transfer & Remainder of your Dana Exchange for In-person Session can be made via cash gift in person or e-transfer after session.

Availability: Our availability does tend to book quickly due to demand, so please anticipate that session bookings will happen within 2-3 weeks after our initial consult. Cancellations? Life happens. As long as you can give me 48 hours notice before cancelling a session, I’m happy to rebook once for a later date. Sessions cancelled within 24 hours will not be refunded nor moved unless certain situations require it (medical emergencies etc).

Additional Resources 

https://www.nature.com/articles/d41591-025-00062-4